Adenosine Triphosphate ATP Citrate Lyase ACL Inhibitors Hypocholesterolemic Agents Essay

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Hypocholesterolemic Agents: Adenosine Triphosphate (ATP) Citrate Lyase (ACL) InhibitorsBy limiting cholesterol synthesis in the liver, ATP-citrate lyase (ACL) inhibitors reduce LDLc. The enzyme ACL is upstream of HMG-CoA reductase in the cholesterol production pathway. Bempedoic acid is a novel and, until now, the only licensed adenosine triphosphate citrate lyase inhibitor that operates through the cholesterol-synthesis pathway (much like statins) to reduce LDL-C safely and effectively (Brandts & Ray, 2020). Because it is a prodrug, it is activated in the hepatocyte, avoiding the muscular side effects that statins might cause.ACL as compared to Statinsi. Mechanism of actionACL is a non-mitochondrial enzyme abundant in lipogenic tissues like the liver and adipose tissue. ACL catalyzes the conversion of cytosolic Acetyl-CoA and oxaloacetate from mitochondrial-derived citrate, with Acetyl-CoA acting as a common substrate for de-novo cholesterol and fatty acid synthesis (Govindaraju & Sabarathinam, 2021). The sterol regulatory element-binding protein-1 (SREBP-1) regulates ACL transcription and is particularly responsive to dietary status via insulin signaling and glucose metabolites. ACL expression and cytosolic citrate levels are enhanced in the lipogenic state, and they serve as a crucial connection between glycolysis and lipid production and storage. Due to its strategic position in cholesterol manufacturing pathways, ACL inhibition is considered an appealing treatment option for lowering increased LDL-C levels.On the other hand, statins, which are highly powerful and selective inhibitors of HMG-CoA reductase, block de-novo hepatic cholesterol synthesis, which is an effective treatment method for lowering LDL-C.

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…and tendon injury are all possible side effects of bempedoic acid (Cicero et al., 2020). Some side effects can be dangerous; therefore, if a patient notices any of these signs or symptoms, they should stop taking bempedoic acid right away and call a doctor or seek emergency medical attention: significant joint pain, redness, warmth, soreness, swelling, especially in the big toe area; hearing or feeling a snap or crack in a tendon area; bruising following a tendon injury; or difficulty to move to or bear weight on the damaged tendon area.Common side effects associated with statins are headaches, nausea, and muscle and joint aches. Occasionally, statins can produce more serious side effects, such as high blood sugar or type 2 diabetes, muscle cell….....

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