Analgesic Systems: Roles of Stress Research Paper

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Gonadectomy alters the magnitude of CCWS and ICWS analgesia and alters the relationship between the gender-specific effects observed in sham-treated rats. Castration significantly decreased the magnitude of CCWS analgesia on the tail-flick and jump tests, and the magnitude of ICWS analgesia on the jump test. Indeed castration reduced the magnitude of CCWS and ICWS analgesia in males to that observed for sham-treated female rats.

Conclusion

Given the multitude of CNS substrates and systems underlying both opioid and stress analgesia, and the likelihood that only a little differ amid sexes, we could rationally expect to come across sex differences in opioid analgesic efficacy in some occasions, depending solely on the nature of the ache incentive and opioid involved, as outlined earlier.

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It is important to also note that sex differences are no defined to opioid drugs in analgesia. Furthermore, commencement of endogenous pain inhibitory mechanisms in reaction to stress also produces magnitudes of analgesia that vary between the sexes.

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