Bridging Spinal Cord Injuries by Research Proposal

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Fawcett compares uses a freeway analogy to describe this, saying the axons have no problem with the onramp (growing onto the PNS bridge), but get stuck at the off-ramp (leaving the PNS tissue). Why axons can't simply get "on" from both sides and meet in the middle is not addressed in this paper; presumably the axons grow only in one direction.

Davies and colleagues created two different types of astrocytes using the same stem-cell derived precursors. One proved to be an effective bridge, the other actually inhibited axon growth but stimulated the growth o pain receptors, increasing pain at the injury site. The fact that the two astrocytes are so closely related is worrisome, as it may lead to complications in large-scale or human applications.

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Also, there could be problems in obtaining the useful kind of astrocyte. Right now, all work is being conducted on rats in a lab, where the transplant occurs at the time of the injury and the stem cells are in ready supply. Different factors exist for humans in the….....

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