Burnand, Y.; Andreoli, A.; Kolatte, Research Proposal

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The researchers were also careful to note established differences in response to psychodynamic therapy based on the personality of the patient and other factors, and took steps to control this during their analysis of the results, as well. Nurses with an extensive background and proven ability in dealing with patients suffering from major depression were used to treat all the patients, especially in the support sessions, and the nurses treating the patients that were receiving both clomipramine and psychodynamic therapy met once a week with a psychoanalyst to go over protocol and develop techniques. The main goal of the researchers in having the nurses acquire these techniques was an attempt to surmount any barriers to the psychodynamic treatment that might arise, as such blocks are well documented during psychodynamic therapy and could produce unusable results from an otherwise carefully controlled study.

Clomipramine protocol was somewhat more simple, with the dosage beginning at 25mg on the first day of the study and gradually increasing to 125mg by the fifth day. Electrocardiograms were administered to ensure that no adverse effects were taking place, and clinicians were able to adjust patients' levels of clomipramine individually once the idela blood saturation of the drug had been reached. Pateints entering the study were also rated for the degree of their depression, including the timing and severity of recent episodes, and this data was also analyzed as part of the study's results.

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Days spent hospitalized or away from work due to depression were also monitored, and none of the nurses or clinicians who had worked with the patients were involved in the analysis of the results to ensure that there was no way to taint the data collected or the conclusions drawn from a statistical analysis of this data.

After ten weeks in the trial, those who were receiving both psychodynamic therapy and clomipramine were far less likely to report feelings of treatment failure than were those who had received clomipramine alone. There was also a notable difference in the group receiving both therapies and those receiving only clomipramine in the number of days spent hospitalized or simply missing work due to depression, with those receiving both therapies remaining generally more productive and less depressed. This difference was not notable in the groups prior to the start of the trial. This in turn translates to a cost savings despite the extra cost of psychodynamic therapy in tandem with clomipramine. The researchers' hypothesis was upheld by their research, and combining psychodynamic with drug therapies is seen to….....

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