Clinical Uses Enzymes Medicine Diagnostics Assessment

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CLINICAL USES OF ENZYMES

Clinical Uses of Enzymes


Our bodies are a masterpiece in terms of design – with fine-tuned processes that point to a supreme designer. This discussion reminds me of Psalm 139:14 – we are indeed fearfully and wonderfully made. Enzymes are complex proteins or biocatalysts in the body that catalyze biological systems 1,3. Essentially, enzymes speed up chemical reactions without being changed by the said reaction. Owing to their remarkable catalytic properties, enzymes are used in various metabolic activities. This is more so the case given that reactions that have been catalyzed by enzymes tend to be of high efficiency1. The diagnostic use of enzymes is based on the fact that enzymes can be used to measure any content or changes of specific substances in the body2. Essentially, enzymes are substrate specific and their activity can be measured while other proteins are present. This involves the use of diagnostic enzymes which are essentially used for prognosis of diagnosis. Many metabolic diseases are caused by abnormalities in enzyme metabolism. This is more so the case given that various diseases lead to damage of tissues depending on their onset and severity2. Therefore, enzyme metabolic systems are used as markers of certain diseases in research owing to the metabolic relationship to enzyme metabolism system2.

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For instance, enzymes are used as markers in inflammatory and autoimmune disorders and bone diseases. One such enzyme…

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…The urokinase enzyme is used in the said therapy. The substrate form of enzyme urokinase is plasminogen which happens to be the inactive form of plasmin. Therefore, plasminogen is converted to plasmin by the said enzyme3. The said conversion happens to be useful in the treatment of cardiovascular diseases owing to the fact that plasmin prevents the proteolytic cascade from participating in thrombosis which is involved in destruction of extra-cellular matrix 3. Clinical research on peptidase is ongoing owing to their increased capacity to degrade deposits of proteins in tissues. For instance, metalloprotease endopeptidases such as MMP-9 and matric metallopeptidase are been studied for the treatment of diseases such as fibriosis conditions. These occur….....

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