Diabetes Is One of the Thesis

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However, advancements in pharmacogenetics promises new and better ways of managing diabetes. Studies have shown that Lisofylline, an anti-inflammatory compound is very effective in suppressing the autoimmune activity and in improving the islet secretion of insulin. Mice studies showed significant difference (25% vs. 91.6%) in the onset of diabetes among Lisofylline treated mice compared to placebo mice. Reduction of inflammatory cytokines IFN-? And TNF-? levels correlated with reduction in ss cell apoptosis. [Yang et.al, 2003] Recent study by Lipsett et.al (2007) has shown that Islet Neogenesis-Associated Protein (INGAP) is useful as a pancreatic regeneration agent. Successful tests in mice and regeneration of cultured human pancreatic cells have encouraged the researchers to seriously consider INGAP as an effective agent for improving insulin synthesis. [Lipsett et.al, (2007)]

A recent Cornell University study focused on an entirely different approach to diabetes management. The researchers examined the possibility of recombinant Commensal bacteria engineered to secrete insulinotropic proteins GLP-1 and PDX-1. The study revealed that the GLP-1 and PDX-1 proteins secreted in the gut bacteria were able to stimulate the intestinal epithelial cells to secrete insulin in response to glucose. This method has the added advantage that commensal bacteria are well tolerated and therefore cause no adverse reactions.

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Conclusion

The pandemic nature of diabetes and the increasing number of diabetics necessitates a sense of urgency in the prevention, control and management of this chronic condition. As an autoimmune and polygenic disorder, diabetes presents a complex challenge to the health care sector worldwide. The ever-increasing diabetic population places a huge strain on the available insulin resources and has forced researchers to consider new biotechnological therapeutics in the treatment of the condition. While Insulin therapy and appropriate Immunosuppressive treatment are the frontline therapy in the effective management of Type 1 diabetes, the growing field of pharmacogetics in diabetes promises to offer novel and effective therapies which would regenerate the bodies natural insulin production system. With our increasing understanding of the genetic factors of diabetes, genetic therapy promises to be vital in the battle against the condition. Recombinant synthesis of insulin and genetically modified probiotics promise a great revolution in the management of diabetes. There is little doubt that the biotechnology way would be central in the effective management of this chronic condition......

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portion of the U.S. population as they account for over 50 million people. Diabetes is one of the major health issues among this population with prevalence rates estimated at 18.3% for diagnosed and undiagnosed patients (Sentell & Braun, 2012). The prevalence rates of diabetes among elderly Hispanics remain relatively high. Elderly Hispanics are predisposed to diabetes because of various factors such as limited knowledge, cardiometabolic abnormalities, and lack of access to resources. The prevalence rates of diabetes among Hispanics are significantly higher in comparison to non-Hispanic populations. Diabetes disorders among this population are associated with other health conditions like end-stage renal disease (Office… Continue Reading...

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