Muscle Fatigue - Annotated Bibliography Term Paper

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Bellinger, a.M., Mongillo, M., & Marks, a.R. (2008). Stressed out: the skeletal muscle

Ryanodine receptor as a target of stress. Journal of Clinical Investigations. 118(2):

In this report prior the researchers addressed overall present understanding of muscle fatigue. For decades, the mechanisms underlying muscle fatigue and weakness were the emphasis of numerous studies. The dominant theory was that lactic acidosis caused muscle fatigue. However, dysregulation of sarcoplasmic reticulum (SR) Ca2+ release has been associated with impaired muscle function induced by a variety of stressors, from dystrophy to heart failure to muscle fatigue. Here, the authors addressed the topic of the altered regulation of SR Ca2+ release during chronic stress and focused on the role the release channel known as the type 1 ryanodine receptor plays.

Kolata, G. (2008, February 12.).

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Finds may solve riddle of muscle fatigue in muscles.

New York Times. Research. Retrieved February 23, 2008 at http://www.nytimes.com/2008/02/12/health/research/12musc.html?ref=science

Based on their studies of muscle fatigue, investigators under the lead of Andrew Marks of Columbia University developed a drug called rycals, because it attaches to the ryanodine receptor/calcium release channel in heart muscle cells. The investigators tested rycals in mice and found that they could prevent heart failure and arrhythmias. Columbia hopes to start testing one of the drugs for safety in patients for congestive heart failure in the spring. Marks, recognizing that the same mechanism might apply to skeletal as well as heart muscle, gave the drugs to the exhausted mice and they could run 10 to 20% longer......

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