Nutrition a Human Body Includes Thesis

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The initial, dramatic increase in the body's production of TNF-alpha in response to viral exposure demonstrates a heightened immunological response targeted to the protection against infection.

Viral respiratory tract infections, such as cold and influenza, are the most common human illnesses. They have significant health and economic consequences, particularly with young children and youth, older individuals and those with other underlying or chronic conditions. Annually, an average of 5 to 20% of Americans contract influenza, with over 200,000 being hospitalized with influenza-related complications and about 36,000 dying from the disease. It is also estimated that 1 billion colds occur each year in the U.S. Only medications that help with the symptoms medications and homeopathic remedies have been available until this time. Due to these high incidence rates, a safe and effective alternative is clearly needed to reduce the burden of illness.

Although the study did not directly evaluate an immune response to the specific swine flu virus, H1N1, good reason exists to conclude that Bacillus coagulans could boost the body's natural defenses to fight a variety of flu viruses, including swine flu, as well. The study helps support the long-suspected belief about the beneficial effects of GanedenBC30 on the immune system and adds to the emerging body of evidence that probiotics can benefit healthy people as well as those with specific health issues.

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While additional research is needed to demonstrate whether this translates into reduced hospitalization and/or deaths, it's a healthy, low-cost, proactive thing that people can do that has no risks associated with it.

Regardless of the strain and its potential effect, probiotics need to survive gastric and bile acids so that they can reach the intestinal tract, colonize the host epithelium, and exhibit an advantageous effect. However, most conventional forms of lactobacilli probiotics are inactivated by bile and have a low gastric pH. On the other hand, spore-bearing, lactic acid-forming bacteria, such as GanedenBC30, are protected by a hardened spore coating that can withstand gastric and bile acid for delivery to the small and large intestines. This may partly explain why GanedenBC30 stimulated a significant immune response while other forms of probiotics tried in the study have not.

Further, any probiotics that are chosen for commercial use must survive industrial manufacturing and storage to ensure long-term viability and activity. However, most cells of conventional lactobacilli die at 70°C, while spore-bearing, lactic acid-forming bacteria do not show a decrease in viable cells even after heating in saline at 85°C for 30 minutes. In addition to surviving heat, gastric acidity, and bile, GanedenBC30 maintains spore viability without the need for refrigeration. This makes it an ideal product for commercial use......

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