Ovarian Cancer and Cancer Term Paper

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Phenoxodiol, a Medication for Cancer

Clinical studies have predominantly focused on a couple of standard benzopyrans, namely flavopiridol and phenoxodiol (by Novogen, via MEI Pharma, the company's subsidiary at the time). Although a benzopyran, the former's method of action apparently differs from phenoxodiol's action neither of the two aforementioned benzopyrans has gained FDA (Food and Drug Administration) or EMA (European Medicines Agency) approval. The height of research on phenoxodiol was one 'Phase III' research on resistant cancer cells in the ovaries. Although slow recruitment led the trial at this phase to formally close down, results clearly displayed that oral consumption of phenoxodiol would most probably not have benefited patients, if the trial phase had been completed. Phenoxodiol results (in combination with others) led to the following hypothesis by Novogen: the problem with phenoxodiol pertained to bioavailability (in other words, the ingested drug wasn't reaching the site of cancer in adequate quantities); thus, there was a lack of adequate activity at the site of the cancer (Marc Sinatra, 2015).

The project which resulted in Cantrixil's development was, apparently, initially focused on seeking phenoxodiol's successor to treat ovarian cancer. While the end product of the experiment is nevertheless associated with ovarian cancer, it is being aimed at pleural and peritoneal cancers.

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Further, organizations and the involved executive team have a superior grasp of available technologies (Marc Sinatra, 2015).

Presenting Phenoxodiol with improved Solution

Phenoxodiol represents an isoflavone equivalent with antitumor function against several kinds of cancers. The researchers of a recent study explored phenoxodiol's impacts on cancer cells in the human gallbladder, in an attempt to ascertain if phenoxodiol was capable of enhancing gemcitabine antitumor activity in case of gallbladder cancer. A combination of gemcitabine-phenoxodiol proved to be a more potent treatment, when it came to cell proliferation inhibition, as compared to both chemotherapeutic agents alone. Moreover, antitumor impacts of a gemcitabine-phenoxodiol combination on cancer cells in the gallbladder was studied via a mouse xenograft model for gallbladder cancer; results indicated that phenoxodiol led to enhanced in-vivo gemcitabine antitumor activity. Taken together, the research work indicated that gemcitabine-phenoxodiol combination treatment can provide optimal therapeutic advantages for gallbladder-cancer patients (Yu Li, Xiaoqiang Huang, Zhiqiang Huang, & Jian Feng, 2014). Phenoxodiol represents a new-gen anti-cancer medication coming under the 'signal transduction inhibitor' category of drugs, which induce programmed cancer-cell death (apoptosis), and have no or minimal impact on the normal cells in the patient's….....

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