Polycythemia Vera and Lou Gehrig's Disease Polycythemia Essay

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Polycythemia Vera and Lou Gehrig's Disease

Polycythemia Vera (PV)

PV is in basic terms "a stem cell disorder characterized by proliferation of a clone of hematopoietic precursors, nearly all of which arise from a mutation in the JAK2 (janus kinase 2) gene" (Hines & Marschall, 2012, p.417). Being a bone marrow disease, PV leads to what MedicinePlus (2013), a U.S. National Library of Medicine service, refers to as an unusual increase in primary red blood cell numbers.

Symptoms and Causes

Some of the symptoms of this PV include but they are not limited to fatigue and shortness of breath, reddened and itchy skin, dizziness and unexplained headaches, and breathing difficulties (MedicinePlus, 2013). Other symptoms in this case could include unexplained weight loss and general body weakness.

PV essentially comes about when there is a problem with the production of blood cells as a result of a mutation in the affected individual's bone marrow cell. The exact cause of the said mutation is not known (MedicinePlus, 2013).

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Complications

Hyperviscosity could lead to "thrombosis of small vessels, with ruddy cyanosis of the nose and clubbing (stunting) of the digits (Mills, 2005). PV could also trigger blood clots as it is known to thicken blood. The said blood clots could increase an individual's risk of suffering a heart attack or stroke. Other complications associated with PV include myelofibrosis and gout (MedicinePlus, 2013).

Treatment

Treatment of PV according to MedicinePlus (2013) largely concerns itself with reducing blood thickness so as to reduce chances of clotting. Yet another goal of treatment in this case is the reduction of the amount of blood cells. This could be done via the administration of chemotherapy (MedicinePlus, 2013).

Lou Gehrig's Disease

Also referred to as amyotrophic lateral sclerosis (ALS), Lou Gehrig's disease according to the ALS Association (2010) "is….....

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