Research on AIDS Control Essay

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Statistical Evidence Used to Support Early Study Termination

Study population, comprising two clusters, namely AIDS patients and those suffering from AIDS-related complex, was a factor that supported early termination of the study. Statistical evidence employed was that AIDS patients who suffered from pneumonia many times were included in the study. On the other hand, patients who suffered multiple Pneumocystis carinii pneumonia (PCP) episodes were excluded from the study. Thus, the research, comprising 27 participants who had spent 24 weeks in the study, 152 participants with16 weeks' participation and others had completed at least 8 weeks' of participation. At this point, 19 recipients of placebo and 1 recipient of 1 AZT (Azidothymidine) died during the study (Fischl et al., 1987).

Are you for or against the early termination and why?

The idea of early termination is not considered favorable, since the study proved valuable in treating the clinical condition, virus replication and immune function. As this study was created as a randomized double blind placebo control (RDBPC) trial with duration of 24 weeks, the mortality rate would have been significantly reduced almost to zero. Patients could, be taught to receive placebo or AZT for immunity. Numerous indicators reveal that AZT's toxicity and the resulting dosage reduction may have contributed to treatment failure, and in turn, failure to sustain study benefits to participants.

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Also, the smaller variation between placebo- and AZT- receiving groups following 20 weeks into the study might be artifactual (Fischl et al., 1987).

Propose an observational study that might contribute to an understanding of why some people develop AIDS and others do not A Priority Research Agenda study (A Priority Research Agenda, 2010).

Why some people develop AIDS and others do not In a majority of cases, absence of protective variants makes cells infected with HIV undetectable by the immune system. Scientists, for example, have proven earlier that individuals with immune systems capable of controlling HIV will most probably possess specific "flavors" of a key immune trait known as Human Leukocyte Antigen (or HLA). This system enables the human body to differentiate between body cells that are healthy and cells that foreign agents (e.g. viruses) have infected. An area of the 6th chromosome which encodes for HLA holds genetic commands for the newly found amino acid variants. Five out of six of these variants lie within a CD4-controlling protein (which governs how CD4s (a category of immune cells) exhibit….....

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