Does Vitamin D Supplementation Improve Glycemic Control in Type 2 Diabetics? Capstone Project

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Acceptable Recruitment Methods

Acceptable Method of Selection of Controls

Minimization of Bias

Were the Confounders Accounted for in the Study Design

Are the Results Believable

Are They Applicable to Other Populations (Generalizable)

Do the Results Fit with Available Evidence

Jorde & Figenschau, 2009

Yes, as reflected from the title: Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25- hydroxyvitamin D levels

Yes, because patients with poor glycemic control were randomly assigned to control and case group. Also appropriate dosages of Vit. D was used

Place of recruitment was not specified.

Patients were randomly assigned to both groups.

Variables were clearly defined.

Yes, the control group was randomly selected from the actual population

No blinding method used. Compliance was assessed by asking patients to return unused capsules.

Yes, they were: BMI, smoking status, waist to hip ratio, blood pressure, serum calcium, creatinine, lipid profile and 24 hr. urinary calcium.

Yes, because the method used was appropriate and acceptable

No, because of short sample size and short duration of study.

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No, other studies show that Vitamin D improves glycemic control, whereas this study concluded the opposite.

Nikooyeh et al., 2011

Yes, as concluded by the title and end conclusion.

No because a suboptimal dose of Vitamin D was used.

Yes, all participants had impaired fasting glucose levels and were not already taking calcium or Vitamin D supplements.

Yes, the control group was randomly chosen.

Follow-up bias was minimized by twice a week follow ups.

Yes, for example, BMI and anthrometric measures. Correlations between variables was analyzed using Pearsons

No, because vitamin D dosage was suboptimal

No, because of short sample size and short duration of study.

Yes, available evidence also confirm an improvement of glycemic control with Vitamin D supplementation.

Patel et al., 2010

The focus of this article was slightly broader due to the comparison groups between patients receiving subtherapeutic Vitamin D dosing (400 IU daily) and those receiving 1200 IU….....

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