HPV Vaccination According to the Term Paper

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jci.org/cgi/content/full/116/5/1167.

In 2006, an estimated 9,710 cases of invasive cervical cancer will be diagnosed in the United States, and an estimated 3,700 women will die from this disease. Globally, cervical cancer is the second most common cause of cancer death in women, with an estimated 510,000 newly diagnosed cervical cancer cases and 288,000 deaths." Saslow et.al, 2007, at http://caonline.amcancersoc.org/cgi/content/full/57/1/7?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&title=American+Cancer+Society+Guideline+for+Human+Papillomavirus&andorexacttitle=and&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT

HPV is arguably the most common sexually transmitted disease in the United States, with an estimated 24 million active cases and 5.5 million new cases each year. Most people contract a strain of HPV that is suppressed by the immune system with no medical intervention. Other HPV strains cause troublesome genital wads. An even smaller number of HPV strains lead to cervical cancer, which kills around 4,800 women a year -- more than the number of women who die of AIDS."

Cheryl Wetzstein, "HPV Emerging as the Next Epidemic," Insight on the News, 11 December 2000.

Lowy & Schiller, 2006, available online

Saslow et.al, 2007, available online

Tom Coburn, R-Okla., an obstetrician who speaks bluntly about the human papilloma virus (HPV), calling it "a very insidious disease." He has been fighting for more than a year to make HPV a reportable disease like AIDS and to put warnings on condom packages saying that they offer little or no protection against HPV." Cheryl Wetzstein, "HPV Emerging as the Next Epidemic," Insight on the News 11 Dec. 2000.

Officials Question HPV Program," the Washington Times 25 Aug. 2003: A06, Questia, 10 Apr. 2007 http://www.questia.com/PM.qst?a=o&d=5001986370.

Sex-Disease Shot Urged for Girls; Cervical Cancer Linked to HPV," the Washington Times 5 Jan. 2007: A03, Questia, 10 Apr. 2007 http://www.questia.com/PM.qst?a=o&d=5018740372.

In a study that followed women for an average of two years, Merck's genetically engineered vaccine, Gardasil, prevented infection from human papilloma virus (HPV) strains 16 and 18 in all women who received the inoculation.

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Those two HPV strains cause 70% of cervical cancers.Study participants were sexually active women between 16 and 26 who were not infected with HPV strains 16 and 18 at the start of the study. Half of the women in the study received three doses of Gardasil over six months. The other half were administered a dummy shot.By the end of the research, no cases of cervical cancer or precancerous lesions were observed among the vaccinated women, compared with 21 cases in the placebo group."

Vaccine Blocks Cancer Cause; Merck's Drug '100%' against HPV," the Washington Times 7 Oct. 2005: A01, Questia, 10 Apr. 2007 http://www.questia.com/PM.qst?a=o&d=5011234140.

Among women aged 16 to 23 years who completed the vaccination regimen, did not violate the protocol, and who had no virological evidence of infection with the respective HPV vaccine type at study entry through 1 month following the third vaccine dose (vaccine = 2,261 versus placebo = 2,279), vaccine efficacy was 100% (97.5% CI, 88% to 100%) for preventing HPV6/11/16/18-related external genital warts or vulvar/vaginal intraepithelial neoplasia (VIN/VaIN) of any grade. In this population (vaccine = 2,240 versus placebo = 2,258), the vaccine prevented 100% of HPV6/11/16/18-related cervical lesions of any grade. The average follow-up time was approximately 1.5 years following completion of the 3-dose vaccine schedule. (Saslow et.al, 2007, available online)

HPV Vaccines: What You Need to Know," Daily Herald (Arlington Heights, IL) 27 Nov. 2006: 4.

Hold Back Knee-Jerk Reactions on HPV Vaccine," the Washington Times 12 Jan. 2007: B02.

Saslow et.al, 2007, available online.....

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