Negative Feedback Loops the Human Term Paper

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Many times, people who lose weight on very low calorie diets gain it back again due to a resetting of homeostatic mechanisms to a lower than normal value. This reduction in the body's metabolic rate is an attempt by the body to avoid starvation. After the initial weight loss, patients find they gain weight back, even at the lower caloric intake level, simply because a change in the metabolic set point. Some patients may be able to overcome the metabolism by effective levels of exercise, since the metabolism responds to exercise by providing energy for muscle work based on expenditure needs rather than reduced intake.

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It is unlikely that humans are genetically predisposed to metabolic set point reduction. While obesity and weight problems often run in families, no studies to date have associated this issue with genetic problems, except in the very rare cases of congenital abnormality. Rather, it is more likely that patterns of eating, exercise and diet are learned behaviors and this is the cause of similar feedback loops within families as are related to weight loss......

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